An experimental study was conducted to evaluate the toxic effects of cisplatin with respect to oxidative stress and organ toxicity. A total of 48 female Sprague dawley rats of 3 months old were divided as follows: Group 1 Control diet; Group 2 Control diet + Cisplatin @ 2 mg/kg b.wt i/p once in a week; Group 3-Control diet + Turmeric @ 0.05 ppm b.wt daily by oral gavage needle; Group 4- Cisplatin +Turmeric as per above doses and routes of administration. The CPK was significantly (P < 0.05) increased in group 2. The tissue enzyme assays revealed a significant (P < 0.05) increase in TBARS and protein carbonyls and significant (P < 0.05) decrease of GSH in Group 2 compared to other groups. The ameliorative group 4 showed mild to moderate improvement in all parameters in comparison to group 2. Sections from heart revealed marked interfibrillar congestion, haemorrhages in purkinje fibres, disrupted cardiac muscle fibres and round cell infiltration. The study revealed that cisplatin-induced toxicity is attributed to the induction of reactive oxygen species with subsequent depletion of antioxidant defenses and eventual oxidative stress. Supplementation of turmeric was found beneficial in countering the toxic effects of cisplatin.
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